人胃腸道間質瘤細胞GIST882

細胞名稱

人胃腸道間質瘤細胞GIST882

貨物編碼

BFN60808731

產品規格

T25培養瓶x1

1.5ml凍存管x2

細胞數量

1x10^6

1x10^6

保存溫度

37℃

-198℃

運輸方式

常溫保溫運輸

干冰運輸

安全等級

1

用途限制

僅供科研     3類

培養體系

DMEM高糖+10%FBS+1%三抗

培養溫度

37℃

二氧化碳濃度

5%

簡介

人胃腸道間質瘤細胞GIST882取自女性供體。

注釋

倍增時間34h

基因突變

Homozygous for KIT p.Lys642Glu (c.1924A>G) (PubMed=11526490; PubMed=16077968).

HLA信息

STR信息

參考文獻

PubMed=11526490; DOI=10.1038/sj.onc.1204704

Tuveson D.A., Willis N.A., Jacks T., Griffin J.D., Singer S., Fletcher C.D.M., Fletcher J.A., Demetri G.D.

STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.

Oncogene 20:5054-5058(2001)

PubMed=16077968; DOI=10.3892/or.14.3.645

Noma K., Naomoto Y., Gunduz M., Matsuoka J., Yamatsuji T., Shirakawa Y., Nobuhisa T., Okawa T., Takaoka M., Tomono Y., Hiroyuki O., Gunduz E., Tanaka N.

Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.

Oncol. Rep. 14:645-650(2005)

PubMed=16982758; DOI=10.1158/0008-5472.CAN-06-0165

Bauer S., Yu L.K., Demetri G.D., Fletcher J.A.

Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.

Cancer Res. 66:9153-9161(2006)

PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004

Muhlenberg T., Zhang Y., Wagner A.J., Grabellus F., Bradner J., Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.

Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.

Cancer Res. 69:6941-6950(2009)