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    產品展示 / products 您的位置:網站首頁 > 產品展示 > 細胞庫 > 細胞系 > 人甲狀腺癌乳頭狀細胞BCPAP
    人甲狀腺癌乳頭狀細胞BCPAP

    人甲狀腺癌乳頭狀細胞BCPAP

    簡要描述:青旗(上海)生物技術發展有限公司,總部位于上海浦東新區,依托本地高校資源,逐步發展成為以生物技術為主的研發、生產、培訓為一體的綜合化產業平臺,在標準化細胞庫建立及細胞藥物前端模型方面成果顯著。公司生產經營原代細胞、細胞系、ELISA試劑盒、感受態細胞和HPLC檢測等科研產品與服務。我們秉承對用戶負責的態度,以對科研的高度嚴謹,以嚴格的質量控制,為廣大生物醫學科研用戶提供更優質的服務!

    更新時間:2021-05-25

    廠商性質:生產廠家

    瀏覽次數:412

    詳情介紹
    品牌其他品牌貨號BFN60810525
    規格T25培養瓶x1 1.5ml凍存管x2供貨周期現貨
    主要用途僅供科研應用領域醫療衛生,生物產業

    細胞名稱

    人甲狀腺癌乳頭狀細BCPAP

    img1

    貨物編碼

    BFN60810525

    產品規格

    T25培養x1

    1.5ml凍存x2

    細胞數量

    1x10^6

    1x10^6

    保存溫度

    37

    -198

    運輸方式

    常溫保溫運輸

    干冰運輸

    安全等級

    1

    用途限制

    僅供科   3

     

    培養體系

    DMEM高糖(不含丙酮酸鈉+10%FBS+1%三抗

    培養溫度

    37

    二氧化碳濃度

    5%

    簡介

    人甲狀腺癌乳頭狀細BCPAP76歲女性供體,該細胞源DMSZ

    注釋

    Part of: Cancer Cell Line Encyclopedia (CCLE) project.

    Part of: COSMIC cell lines project.

    Part of: TCGA-110-CL cell line panel.

    Doubling time: ~30 hours (DSMZ).

    Microsatellite instability: Stable (MSS) (Sanger).

    Omics: Deep exome analysis.

    Omics: Deep RNAseq analysis.

    Omics: DNA methylation analysis.

    Omics: SNP array analysis.

    Omics: Transcriptome analysis.

    Caution: Was originally classified a thyroid gland papillary carcinoma (PTC) but is now considered to be a poorly differentiated thyroid gland carcinoma (PDTC) (PubMed=23162534).

    基因突變

    Homozygous for BRAF p.Val600Glu (c.1799T>A) (ClinVar=VCV000013961) (PubMed=23162534; PubMed=23833040; PubMed=30737244).

    Heterozygous for TERT c.228C>T (-124C>T); in promoter (PubMed=23833040; PubMed=30737244).

    Homozygous for TP53 p.Asp259Tyr (c.775G>T) (PubMed=14522906; PubMed=23162534; PubMed=30737244).

    HLA信息

    /

    STR信息

    Amelogenin        X

    CSF1PO        13

    D2S1338        18

    D3S1358        16,17

    D5S818        10,11

    D7S820        10

    D8S1179        12,13

    D13S317        12

    D16S539        11,12

    D18S51        13,17

    D19S433        13.2,15

    D21S11        30,31.2

    FGA        20,23

    Penta D        10,11

    Penta E        5,12,17

    TH01        6,9.3

    TPOX        8,11

    vWA        14,17

    參考文獻

    PubMed=17725429; DOI=10.1089/thy.2007.0097

    Meireles A.M., Preto A., Rocha A.S., Rebocho A.P., Maximo V., Pereira-Castro I., Moreira S., Feijao T., Botelho T., Marques R., Trovisco V., Cirnes L., Alves C., Velho S., Soares P., Sobrinho-Simoes M.

    Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.

    Thyroid 17:707-715(2007)

     

    PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026

    van Staveren W.C.G., Solis D.W., Delys L., Duprez L., Andry G., Franc B., Thomas G., Libert F., Dumont J.E., Detours V., Maenhaut C.

    Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.

    Cancer Res. 67:8113-8120(2007)

     

    PubMed=18713817; DOI=10.1210/jc.2008-1102

    Schweppe R.E., Klopper J.P., Korch C., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A., Smallridge R.C., Haugen B.R.

    Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.

    J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

     

    PubMed=19087340; DOI=10.1186/1471-2407-8-371

    Ribeiro F.R., Meireles A.M., Rocha A.S., Teixeira M.R.

    Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.

    BMC Cancer 8:371-371(2008)

     

    PubMed=20164919; DOI=10.1038/nature08768

    Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.

    Signatures of mutation and selection in the cancer genome.

    Nature 463:893-898(2010)

     

    PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690

    Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.

    Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

    Clin. Cancer Res. 17:7248-7264(2011)

     

    PubMed=22087789; DOI=10.1186/1755-8166-4-26

    Maric I., Viaggi S., Caria P., Frau D.V., Degan P., Vanni R.

    Centrosomal and mitotic abnormalities in cell lines derived from papillary thyroid cancer harboring specific gene alterations.

    Mol. Cytogenet. 4:26-26(2011)

     

    PubMed=22460905; DOI=10.1038/nature11003

    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

    Nature 483:603-607(2012)

     

    PubMed=23162534; DOI=10.3389/fendo.2012.00133

    Saiselet M., Floor S., Tarabichi M., Dom G., Hebrant A., van Staveren W.C.G., Maenhaut C.

    Thyroid cancer cell lines: an overview.

    Front. Endocrinol. 3:133-133(2012)

     

    PubMed=23833040; DOI=10.1210/jc.2013-2383

    Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.

    Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.

    J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

     

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017

    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

    A landscape of pharmacogenomic interactions in cancer.

    Cell 166:740-754(2016)

     

    PubMed=28775782; DOI=10.7150/jca.18855

    Caria P., Pillai R., Dettori T., Frau D.V., Zavattari P., Riva G., Romano G., Pani F., Bentivegna A., Giovannoni R., Pagni F., Sogos V., Vanni R.

    Thyrospheres from B-CPAP cell line with BRAF and TERT promoter mutations have different functional and molecular features than parental cells.

    J. Cancer 8:1629-1639(2017)

     

    PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953

    Landa I., Pozdeyev N., Korch C., Marlow L.A., Smallridge R.C., Copland J.A., Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.

    Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.

    Clin. Cancer Res. 25:3141-3151(2019)

     

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747

    Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.

    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

    Cancer Res. 79:1263-1273(2019)

     

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3

    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

    Next-generation characterization of the Cancer Cell Line Encyclopedia.

    Nature 569:503-508(2019)

     

    PubMed=31395879; DOI=10.1038/s41467-019-11415-2

    Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

    Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

    Nat. Commun. 10:3574-3574(2019)

    青旗(上海)生物技術發展有限公司,總部位于上海浦東新區,依托本地高校資源,逐步發展成為以生物技術為主的研發、生產、培訓為一體的綜合化產業平臺,在標準化細胞庫建立及細胞藥物前端模型方面成果顯著。公司生產經營原代細胞、細胞系、ELISA試劑盒、感受態細胞和HPLC檢測等科研產品與服務。我們秉承對用戶負責的態度,以對科研的高度嚴謹,以嚴格的質量控制,為廣大生物醫學科研用戶提供更優質的服務! 



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